Hemodialysis isa life savingmethod that can offer significant benefits forend stage renal diseases management,butit can havesomeserious complication ifthe patients didn't understandofits causes. The nurse plays a critical role in reducing complications of this method .This study aimedto assess nurse's performance regardinghemodialysis patients,designnursing teachingprotocol for nurses working with hemodialysis patient,and evaluate the effect of implementing the designed teachingprotocol on nurse's performanceand patient outcomes. Research design:Aquasi-experimental research design was utilized in this study. Sample:Convenient sample of (35)nurses and (60)Adult patients who are receiving hemodialysis aged from (18 to 65)years from both sexes.Setting: Thisstudy was conducted in the kidney dialysis unit at Assiut University Hospital. Tools: three tools utilize for data collection were a) Pre/Post test questionnaire sheet for the nurses) b) Observation checklist sheet. c) Patient assessment sheet. Results: Good improvement in the mean knowledge & practice scores were found after the implementing of designedteachingprotocol.In conclusion:Improving nurses' performances canaffectin minimize the incidence of hemodialysis complications. Recommendation:Provide written policy about the standardized nursing care that should be delivered to every patient in the unit.