Background: Depression is not a natural consequence of being old but it is a common problem among older adults that interferes with daily life and normal functioning of them. This study aimed to evaluate the impact of music therapy in reducing depression symptoms among elderly population. Subject and methods: One group pretest and posttest experimental study design was utilized. Geriatric citizen club in City Street and Geriatric clubs of Islamic cultural center in Assiut Governorate- Egypt were the setting. Subjects were included of all elderly aged 60- 79 years old, a total of 42 were recruited for music therapy intervention program during six months period. Personal data and Short Form Geriatric Depression Scale (GDS) were selected to measure the severity of depression. The results: there was a significant improvement in severity of depression (P˂0.001) between pre and posttest of music therapy intervention for depressed elderly. Conclusion: music therapy has been founded as one of the important strategies toward optimal psychosocial wellbeing for reducing depression among elderly population. Recommendations: additional randomized studies using a larger sample size based on appropriate measurements and long-term follow-up are required to verify the effect of music intervention on depression among senior citizen apartments.