Background: Chemotherapy treatment can be a traumatic experience for adults, imagine for kids. Due to adverse effects of cancer treatment on children's mental health, chemotherapy side-effects and positive effects of infusionarium therapy on nausea, vomiting and stress. Purpose: this study was aimed to determine the effect of infusionarium on occurrence of selected physical and emotional complications among children undergoing chemotherapy. Methods: The present study is a quasi-experimental research design done on 60 children undergoing cancer chemotherapy in South Egypt Cancer Institute-Assiut University in Egypt from December 2015 to December 2016. By convenience sampling method and then allocation, they were randomly divided into two groups (30children for each group aged from 3-12 years old) as control and experimental. The data included the demographic questionnaires, all indices of nausea and vomiting were measured by two scales and stress selfassessment questionnaire. Nausea and vomiting and stress questionnaire was performed before and after chemotherapy course. Results: Approximately all indices of nausea and vomiting significantly reduced during and 2hrs post-chemotherapy by infusionarium and exhibited it is as a useful technique for control of nausea and vomiting in children. Significant difference was found between the control and experimental low stress level in the two groups during chemotherapy (p= 0.035), there were more than half of infusionarium group children have low stress level compared to 26.6% of control group children at the same level. This shows the positive and efficient …