Abstract Background: Acute respiratory failure is a sudden and life-threatening deterioration in pulmonary gas exchange, resulting in carbon dioxide retention and inadequate oxygenation approximately 50% to 75% of those patients require ICU hospital stays &and mechanical ventilatory support practices longer than 7 days. Aim: This study aimed to evaluate the effect of implementing nursing practices to support ventilation among patients with acute respiratory failure on their condition. Method: Design: A quasi-experimental research design was used to conduct this research. A convenient sample consisted of 120 patients, they were enrolled in the study group (n=60) and the control group (n=60) was admitted to the chest intensive care unit at Assiut University Hospital. A patient assessment sheet, acute respiratory failure Patient outcomes assessment sheet were used for the collection of data. Results: A significant statistical difference (P<0.05) between both groups concerning the improvement of oxygenation, arterial blood gas, clinical pulmonary infection score, length of chest ICU stay, mechanical ventilator parameters among study group compared to control group subjects after the intervention, thus research hypotheses cane bee supported. Conclusion: Implementing nursing practices to support ventilation among patients with acute respiratory failure effective in improving their outcomes. Recommendation: develop standardized nursing guidelines for patients with acute respiratory failure.