Abstract Background Literature review cited that, Acute respiratory distress syndrome (ARDS) is one of the major manifestations of multiple organ failure syndromes, and is a leading cause of death in the Intensive Care Unit. Aimed this study to evaluate the effect of that an educational program on nurse’s performance about acute respiratory distress syndrome. Design a quasi-experimental (pre/post-test design). Setting critical care units at AlThawra Modern General Hospital Authority in Sana’a-Yemen. Method Sample was (57) critical care nurses that of all nurses working in a selected setting. The tool I: Pre /Post Nurses Questionnaire, tool II: Pre /Post Observation Checklist. Results: As regard age, of nurses were > 25 years (53%), the education level, the nursing diploma was the most (72%), experience year of nurses had an experience of less than 5 years was (65.3%). The implementation of the education program revealed the improvement of critical care nurse's knowledge, practice scores, and levels regarding acute respiratory distress syndrome with high statistical significance difference between pre and postimplementation programs, (p<0.001). Conclusion, it can conclude that implementing an educational program about acute respiratory distress syndrome care is highly effective in inducing improvement in nurses' related knowledge and practice.