Abstract: Background: The majority of dialysis patients complain from restless leg syndrome and how it negatively affects their sleep causing sleep disturbance and insomnia. Aim of the study: to evaluate the effect of sleep hygiene measures and home remedies on minimizing the insomnia and restless leg syndrome. Subjects and Methods: Design; A quasi - experimental (pre/post-test) research design was utilized. Setting: The study was carried out in the hemodialysis unit at Assiut University Hospitals. Sample: The total number of the hemodialysis patients was (356 patients) the assessment conducted on about 50% (180 patients) while sleep hygiene measures and home remedies applied on (90 patients). A purposive sampling technique was utilized. Tools: four tools have been utilized; Tool I: an interview questionnaire sheet to collect patients’ demographic characteristics. Tool II: Insomnia Severity Index. Tool III: Restless Leg Syndrome Screening Questionnaire and Tool IV: sleep hygiene measures and home remedies nursing instructions. Results: Nearly one-third of the studied sample their age ranged between 50 - 65 years old, with a mean of (44.21±11.21) years. The prevalence of insomnia and restless legs syndrome were 42.8 % & 51.7 respectively. The statistical significant difference was found between pre and post application of sleep hygiene measures and home remedies nursing instructions as regards the severity of both insomnia and restless leg syndrome. Conclusion: Giving written sleep hygiene measures and home remedies nursing instructions for patients have an obvious effect in reducing the prevalence and severity of insomnia and restless legs syndrome. Recommendations: Booklet and pamphlets with an Arabic language must be provided for each hemodialysis patient to help them manageing their insomnia and restless leg syndrome. Keywords: Incidence, Insomnia, Home Remedies, Hemodialysis, Sleep Hygiene Measures, and Restless Leg Syndrome