Background: Treatment for patients with deep venous thrombosis relies on persuading the patient to adhere entirely to the therapeutic plan. Patient education is an important aspect in increasing compliance. Aim: To evaluate the effect of teaching booklet on compliance to oral anticoagulant drugs among patients with deep venous thrombosis. Research design: Quasi-experimental research design. Setting: The study was conducted at vascular surgery department and trauma unit at Assiut University Hospital. Sample: A purposive sample of 60 male and female adult patients. This sample was divided into study and control group (30 patient for each) diagnosed with DVT, their age ranged from18 to 65 years. Tools: Tool I: Patient assessment sheet, Tool II: Compliance of patients with medications by using Morisky Medication Adherence Scale. Results: There was a statistically significant difference between study and control group regarding compliance to oral anticoagulant drugs post application of teaching booklet. Conclusion: Teaching booklet was effective in improving patient's compliance to oral anticoagulant drugs, lower incidence of bleeding and recurrence of thrombus among patients with deep venous thrombosis. Recommendations: Teaching booklet for DVT patients to improve adherence to oral anticoagulant should be available in vascular surgery department.