Diabetic foot can lead to significant morbidity and mortality and is considered one of the most feared complications of diabetes. The Aim of the study is to evaluate the effect of self- management training on knowledge and glycemic control for patients with diabetic foot. Subjects and Method: pre / post-test utilized to conduct this study. This study was carried out in the internal medicine department and out patient diabetic clinic, at Assiut University Hospital. Sample convenience sample of (60) adult patients from both sexes their age ranged from (18-65yrs old.). Tools: tool (1): Patient Assessment Questioner. Tool (II): diabetic self- management scale questionnaire. Self- management training for patient with diabetic foot was developed based on patients identified needs. Results: the mean age of patients was 51.4 +12.6 years old. Three quarter of patient had poor knowledge, while after implementation of the self- management training, more than two third of patients had satisfactory level of knowledge about the management of diabetic foot. Conclusion: The findings of the study showed that there was positive connection between total patients’ knowledge and total self -management scales after implementation of the self- management training Recommendations: (Application of programs for modifying risk factors leading to prevent diabetic foot complications).