Background: National End of Life Care featured that most patients (>70%) of hepatic disease dying from liver disease. In this manner there is have to expand familiarity with basic of critical nurse's performance aboutend of life care of hepatic patients. Aim: Present study aimed to evaluate the effect of teaching program on critical care nurses Performance about end of life care for hepatic patients. Setting: Study was led in Intensive care units at El Raghy University Hospital. Subjects: Fourty nurses were included in the study. Tools of data collection: there are two tools used to collect data: (Tool l) Knowledge assessment questionnaire (Tool II) observational check list. All nurses divided into small group and received the teaching program. Evaluate nurses performance Pre and post test was complete immediately after program implementation. Results: There is very highly statistical difference between nurses' knowledge in Pre &Post test program (p<0.05). Most of nurses had unsatisfactory level preknowledge with percentage (77.5%); Also most of Post Study group had satisfactory level with percentage (90.0%). Conclusion: strengthening of basic care nurses knowledge and practices would have a positive impact on their knowledge and practice. Recommendation: Provide education through end of life Nursing Education Consortium modules for all critical care nurses. Keywords: Critical Care Nursing, End of life care, Hepatic Patient & Teaching Program.