Fatigue is frequently reported symptom influencing up to 90% of hepatocellular carcinoma patient .Aim: Evaluate the effectiveness of educational and physical intervention to reduce fatigue for hepatocellular carcinoma patient. Design: Quasi-experimental design. Setting: Viral Hepatitis Treatment Unit at Assuit Health Directorate. Subjects A purposive sample of 60 patients diagnosed with HCC and infected by hepatitis C, B virus or both. Methods Patients in the study group encourage to perform physical exercises in sessions for 6 months follow up and give information about this disease. Tools: two tools were applied Tool I: Patient assessment sheet Tool II: Functional Assessment of Chronic Illness Therapy (Fatigue Scale). Results: There were significant statistical differences existed between study and control groups regarding to patients' fatigue and patients' knowledge of p-value (0.001).There is very high statistical difference between groups regarding practice exercise &relaxation technique of p-value (0.0001). Conclusion: The nursing intervention had statistically significant beneficial effects on improving patient’s outcomes. It recommends replication of nursing intervention of this study on a larger probability sample.