Background: Rehabilitation is a cornerstone in management of mechanically ventilated patients in ICU concerned reducing impairments, preventing complications and reduce weaning time. Therefore, the aim was to identify the effect of early rehabilitation on mechanically ventilated patient's outcomes. Quasi experimental research design was used to conduct this research. This study was carried out at general intensive care unit at Sohag University Hospitals. The sample of this study was consisted of 60 patients, divided into study and control group equally. Tools used in this study; Tool I: Modified patient assessment sheet, Tool II: patients complications assessment sheet, Methods: Each patient of the study group subjects were exposed in addition to routine hospital care to two sessions/day of rehabilitation program until disconnection from mechanical ventilator. However control group subjects were exposed to routine hospital care only. The main results:- Finding of the present study revealed a significant statistical differences (P<0.05) found between both groups in relation to improvement on oxygenation, length of stay on mechanical ventilation, length of ICU stay, respiratory infection, and weaning in study group compared to control group. Conclusion: Applying early rehabilitation for mechanically ventilated patient help to reduce complications and improve the outcomes. Recommendation: Further researches are recommended to include information about the follow-up of these patients out of ICU.