Abstract Myocardial infarction is the irreversible necrosis of heart muscle, secondary to prolonged ischemia. Aim: to recognize the effect of individualized nursing teaching protocol on quality of life for older adult patients post myocardial infarction. Research design: Quasi-experimental study design was utilized. Setting: The study was conducted in intensive care unit(ICU), cardiology wards and out Patient clinic at Assiut University Hospital. Sample: Simple randomsamplings of 60 adult patients were included in the study. They divided into two groups(30 studies and 30controls).The studygroup received individualizednursing teaching protocol, while the controlgroup received routine hospital care. Tools: Four tools were used for data collection: Structure interviewing questionnaire, Myocardial Infarction Dimensional Assessment Scale (MIDAS), Short Form 36 (SF-36) quality of life scale, and individual teaching protocol. Results: more than half of the patients' in the study group were male, married, with a mean of (57.1z7.62). There were significant differences in the intervention group in both total scores of the MIDAS and SF-36 quality of life scales. Conclusion: an improvement in study group was observed in comparison with the control group in the patients’ knowledge after application of nursing teaching protocol and improvement in quality of life led to decrease risk factors by increasing behaviours that protect cardiac health. Recommendation: Individualized nursing teaching protocol should be applied in a Simple Arabic booklet for all cardiac patients before discharge to provide them with simple explanation about safely living with myocardial infarction. Keywords: Myocardial infarction, teaching protocol, and quality of life