Trans-femoral approach for cardiac catheterization has typically been more prevalent. But, radial access has expanded in popularity due to lower complications rate. Aim of the study: Assess radial versus femoral access for coronary angiography or intervention and the effect on the nurses, patients and relatives' satisfaction. Subjects and methods: Descriptive design was utilized. The study was conducted in the Cardiac Catheterization Lab and Cardiology Department at Assiut University Hospital. All available nurses (30), in addition to (200) adult male and female patients, scheduled for coronary angiography or intervention and (200) members of their relatives. Patients were assigned into two groups (femoral and radial). Tools: Three structured interview questionnaire sheet were utilized for nurses, patients, and patients' relatives. Results: two third of nurses (66.7%) and the highest percentage of femoral and radial groups patients and their relatives (63% & 100% respectively) and (55% & 100% respectively) preferred and satisfied with the radial access than femoral access. Also, the largest percentage of femoral and radial groups patients and their relatives (100% & 74% respectively) and (81% & 51% respectively) had unsatisfactory level of knowledge about types of vascular access. Conclusion: The highest percentage of nurses, patients, and relatives preferred and satisfied with radial access than femoral access. The majority of the studied patients and their relatives had unsatisfactory level of knowledge about vascular access types. Recommendations: Equip the cardiac catheterization unit with simple illustrated guidelines cover vascular access types. Cardiologist should share nurses, patients, and relatives' opinions about vascular access types to maintain satisfaction and help in improving the quality of care.