Background: Effective communication is a skill needed by all healthcare professionals, but not all are naturally good at it. Aim: To assess communication skills of healthcare professionals toward their patients. Design: An exploratory mixed-method design was utilized for the current study. Setting: This study was conducted at three hospitals: one general hospital in Minia city and two university hospitals in Assuit city. Subjects: A total of 508 participants were included: 358 nurses, 100 doctors, and 50 patients. Study tool: Included three tools namely: personal data sheet, HP-CSS, and semi-structured interviews (SSIs). Results: Quantitative data indicated that nurses and physicians have high communication skills. Both have statistically significant differences in informative communication and sympathy dimensions. Nurses have high mean scores in overall HPC-SS than physicians. Degree of satisfaction patients perceived is divers between nurses and doctors. Besides the support of qualitative result to this data. Conclusion: Healthcare professionals have high communication skills, but nurses showed a difference from physicians, owing to practicing the skills in different departments. Recommendation: All health care professionals are requires training and practice about effective communication that should be based on the approach of patient-centered.