A simple, accurate and selective colorimetric method was developed and validated for determination of five of 1,4-dihydropyridine drugs (1,4-DHP) using tetrabutylammonium hydroxide reagent (TBAH). The proposed method was based on addition of TBAH to the studied drugs then the produced yellow colors were measured spectrophotometrically. Different variables which affecting the reaction conditions were carefully studied and optimized. Under the optimum conditions, Beer's law was obeyed in the concentration range of 2.50-40.0 μg/mL and the limits of detection were ranged from 0.750-1.956 μg/mL. The proposed method was successfully extended to the pharmaceutical preparations, tablets and capsules. The obtained results were comparable with that obtained by the reference methods.