قسم البحث
مجلة البحث
J. Nat. Prod., dx.doi.org/10.1021/np400952d
تصنيف البحث
1
عدد البحث
Vol. 77, No. 2
سنة البحث
2014
المشارك في البحث
ملخص البحث
Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H−J (1−3). Extensive use was made of 1D and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 μM.