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Activity and Structure Elucidation of Ceramides

مؤلف البحث
E. S. Elkhayat, G. A. Mohamed, S. R. M. Ibrahim
قسم البحث
مجلة البحث
Current Bioactive Compounds
تصنيف البحث
1
عدد البحث
Vol. 8, No. 4
سنة البحث
2012
المشارك في البحث
ملخص البحث

Ceramide, a derivative of sphingolipid breakdown products, acts as second messenger for multiple extracellular stimuli including growth factors, chemical agents, and environmental stresses. They have been shown to be crtically involved in various biological processes, including differentiation, senescence, cell-cycle arrest, proliferation, and apoptosis. Ceramide molecules form distinct domains in the cell membrane, which may serve to re-organize cellular receptors and signaling molecules. Because of their promising biological activities and applications, here we focus on: biosynthesis, existence, importance, and structure elucidation, as well as representative examples concerning their structure and activity.