As a part of our continuing interest in identifying anticancer drug leads from natural sources, we have
investigated the in vitro growth inhibitory effects of the hexane fraction of the root bark of Calotropis
procera (Ait) R. Br. (Asclepiadaceae). This study reports the isolation and structure elucidation of four new ursane-type triterpenes named calotroprocerol A (1), calotroproceryl acetate A (2), calotroprocerone A (3) and calotroproceryl acetate B (4) in addition to five known compounds including pseudotaraxasterol acetate (5), taraxasterol (6), calotropursenyl acetate B (7), stigmasterol (8) and (E)-octadec-7-enoic acid (9). Their structures were established on the basis of 1D and 2D NMR studies (1H–1H COSY,HSQC, and HMBC) and HRMS spectral data. The in vitro growth inhibitory activity of the isolated compounds was evaluated against three human cancer cell lines including the A549 non-small cell lung cancer (NSCLC), the U373 glioblastoma (GBM) and the PC-3 prostate cancer cell lines.
قسم البحث
مجلة البحث
Phytochemistry Letters
الناشر
Elsevier
تصنيف البحث
1
عدد البحث
5
موقع البحث
http://dx.doi.org/10.1016/j.phytol.2012.04.012
سنة البحث
2012
المشارك في البحث
ملخص البحث