Pyridoacridines are a class of strictly marine-derived alkaloids that constitute one of the largest chemical families of marine
alkaloids. During the last few years, both natural pyridoacridines and their analogues have constituted excellent targets for
synthetic works. They have been the subject of intense study due to their significant biological activities; cytotoxic, antibacterial,
antifungal, antiviral, insecticidal, anti-HIV, and anti-parasitic activities. In the present review, 95 pyridoacridine alkaloids isolated
from marine organisms are discussed in term of their occurrence, biosynthesis, biological activities, and structural assig