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A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro.

مؤلف البحث
El-Gamal A. A., Abd-El-Halim M. F., Kalil A.T., Basudan O. A., Al-Rehaily A., Ahmad M. S., El-Tahir K. H., Al-Massarani S. M., Abdel-Mageed W. M.
قسم البحث
مجلة البحث
Pak J Pharm Sci
الناشر
NULL
تصنيف البحث
1
عدد البحث
Vol.28, No.2
موقع البحث
http://www.pjps.pk/wp-content/uploads/pdfs/28/2/Supplementary/15-SUP-243.pdf
سنة البحث
2015
المشارك في البحث
ملخص البحث

Abstract: A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia
lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced
guinea-pigs’ platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by
measuring 1D and 2D NMR, two of them are the triterpenes β- amyrin and 11α, 12α-oxidotaraxerol, two ceramide
derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin.