Glibenclamide (GLC) is a potent oral hypoglycemic drug widely-used in the treatment of type II diabetes mellitus. It is practically-insoluble in water which hindering its dissolution at the gastric pH hence, lowering its absorption and oral bioavailability (45% only. The aim of this work was to improve such dissolution via formulation of adsorbates and co-adsorbates to enhance the oral bioavailability of GLC. This will enable its use at a lower dose to minimize the cost and possible side effects. Adsorption of drug onto different adsorbents including Laponite RD, Laponite FP, Neusilin US2, Aerosil 200 and Florite R was studied and Langmuir adsorption isotherms were constructed. Moreover, the effect of surfactant addition on the adsorption process was studied also using different concentrations of different surfactants namely; Tween 80, Pluronic F-127 and Pluronic F-68. Laponite RD as an adsorbent and Pluronic F-68 as a surfactant showed the best results and therefore, they were used in the formulation of adsorbates and co-adsorbates. Adsorbates of drug with Laponite RD were prepared in different weight ratios using two different techniques; physical mixing and solvent evaporation technique. Co-adsorbates of drug with pluronic F-68 and Laponite RD were prepared in different weight ratios by solvent evaporation technique. The prepared systems were tested for their drug content and in-vitro dissolution rate. The results showed marked enhancement of GLC in-vitro dissolution rate compared with untreated GLC which would be promising in further incorporation of the optimized formulation into several dosage forms with enhanced bioavailability.