قسم البحث
مجلة البحث
Synlett
الناشر
Georg Thieme Verlag Stuttgart · New York
تصنيف البحث
1
عدد البحث
Vol. 26 - No. 9
موقع البحث
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1380509?lang=de
سنة البحث
2015
المشارك في البحث
ملخص البحث
The first total synthesis of cystobactamid 507, a member of a class of new natural products with strong inhibitory activity towards bacterial topoisomerases, is reported. Synthetic key challenges are the central tetrasubstitued arene and the low chemical reactivity of anilines and ortho-phenolic and isopropoxy-substituted benzoic acids. Biological evaluations demonstrate that cystobactamid 507 inhibits several Gram-positive pathogens but at significantly lower concentrations than described for the larger members of this natural product family.