A simple and non-destructive FTIRmethodwas used to determine certain proton pumpinhibitors (PPIs) in binary
and ternary mixtures. Proton pump inhibitors (PPIs); omeprazole (OMZ), esomeprazole (EZM), lansoprazole
(LAN), pantoprazole sodium (PAN sodium) and rabeprazole sodium (RAB sodium) in binary mixture with
domperidone (DOM) and ternary mixture of OMZ, clarithromycin (CLM) and tinidazole (TNZ) were determined
in the solid-state by FTIR spectroscopy for the first time. The method was validated according to ICH-guidelines
where linearitywas ranged from20 to 850 μg/g and 20–360 μg/g for PPIs and DOM, respectively in binarymixtures
and 10–400, 100–8000 and 150–14,000 μg/g forOMZ, CLMand TNZ, respectively. Limits of detectionwere found to
be 6–100 and 9–100 μg/g for PPIs and DOM, respectively and 4, 40 and 50 μg/g forOMZ, CLMand TNZ, respectively.
The method was applied successfully for determination of the cited drugs in their respective pharmaceutical dosage
forms.