The poor physicochemical properties of rosuvastatin calcium (ROS) remains a challenge for dosage form development. In the present study, we explore the development of spray dried ROS loaded PVP microparticles to improve the release of ROS as well as the anti-hyperlipidemic efficacy. The ROS loaded PVP microparticles (F1–F3)were developed byspraydryingmethod witharangeofparticle size(1.26–1.67μm), PDI(0.138-0.267), PDE (78 ± 3.2 to 89 ± 4.1%), PDL and (14.8 ± 1.2 to 39.4 ± 3.3%). The ROS loaded microparticles (F3) was optimized based on preliminary characterization and further evaluated for DSC, FTIR, SEM, in vitro release studies and anti-hyperlipidemic activity. Overall, It was proved that spray dried PVP microparticles was efficient carrier to deliver rosuvastatin with improved serum lipid profile of hyperlipidemic rats.