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Department of Medicinal Chemistry

Researches Our research spans a wide range from basic organic synthesis, drug design and development, structure elucidation of newly synthesized compound and natural products. The research focuses on the following strategic Research Themes: Design and synthesis of new chemical entities. Computer aided drug design studies. Structure-Activity relationship studies. Combinatorial chemistry. Prod rugs developments. Analytical methods for bioavailability and metabolic studies. Research within these Themes is carried out in multidisciplinary groupings focused on the discovery of novel techniques and/or enhancement of the already existing ones. At the department of Medicinal Pharmacy, We have major national and international collaborative research projects and a significant output of research publications in high-ranking journals. Our academic collaborators include many Universities in USA, Canada, Japan, and a number of major European universities.

# Title Research Year
21 Design and Synthesis of Novel 1,3,4-Oxadiazole and 1,2,4-Triazole Derivatives as Cyclooxygenase-2 Inhibitors with Anti-inflammatory and Antioxidant activity in LPS-stimulated RAW264.7 Macrophages 2022
22 New Cell Cycle Checkpoint Pathways Regulators with 2-Oxo-indoline Scaffold as Potential Anticancer Agents: Design, Synthesis, Biological Activities and In Silico Studies 2022
23 Inversion Kinetics of Some E/Z 3-(Benzylidene)-2-Oxo-indoline Derivatives and Their In Silico CDK2 Docking Studies 2021
24 Inversion Kinetics of Some E/Z 3-(Benzylidene)-2-Oxo-indoline Derivatives and Their In Silico CDK2 Docking Studies 2021
25 Lipophilicity study of different cephalosporins: Computational prediction of minimum inhibitory concentration using salting-out chromatography 2021
26 Inversion Kinetics of Some E/Z 3-(Benzylidene)-2-Oxo-indoline Derivatives and Their In Silico CDK2 Docking Studies 2021
27 Inversion Kinetics of Some E/Z 3-(Benzylidene)-2-Oxo-indoline Derivatives and Their In Silico CDK2 Docking Studies 2021
28 Crystal structure and quantum chemical calculations of (E)1-benzyl-3-((4-methoxyphenyl)imino)-5-methylindolin-2-one 2021
29 Novel 2-Indolinone Based derivatives Targeting Cell Cycle Checkpoint’s Proteins as Potential Anticancer Agents 2021
30 Design and synthesis of some 1,3,5-tri-substituted oxindole derivatives as potential CDK inhibitors 2020