Research Department
Research Journal
Chem. Commun., DOI: 10.1039/B924519G
Research Rank
1
Research Vol
Vol. 46
Research Year
2010
Research Member
Research Abstract
The utility of wild-type and variant carboxymethylproline synthases for biocatalysis was demonstrated by preparing functionalised 5-, 6- and 7-membered N-heterocycles from amino acid aldehydes and (alkylated) malonyl-coenzyme A derivatives; the N-heterocycles produced were converted to the corresponding bicyclic β-lactams by a carbapenem synthetase.