Research Department
Research Journal
ChemBioChem, doi: 10.1002/cbic. 201000641
Research Rank
1
Research Vol
Vol. 12
Research Year
2011
Research Member
Research Abstract
Amino acid analyses reveal that JMJD6-catalysed hydroxylation of RNA-splicing regulatory protein fragments occurs to give hydroxylysine products with 5S stereochemistry. This contrasts with collagen lysyl hydroxylases, which give 5R-hydroxylated products. The work suggests that more than one subfamily of lysyl hydroxylases has evolved and illustrates the importance of stereochemical assignments in proteomic analyses.