Research Department
Research Journal
NATURE CHEMICAL BIOLOGY
Research Rank
1
Research Vol
Volume 8, Issue 12
Research Website
http://www.nature.com/nchembio/journal/v8/n12/full/nchembio.1093.html
Research Year
2012
Research Member
Research Abstract
The finding that oxygenase-catalyzed protein hydroxylation regulates animal transcription raises questions as to whether the translation machinery and prokaryotic proteins are analogously modified. Escherichia coli ycfD is a growth-regulating 2-oxoglutarate oxygenase catalyzing arginyl hydroxylation of the ribosomal protein Rpl16. Human ycfD homologs, Myc-induced nuclear antigen (MINA53) and NO66, are also linked to growth and catalyze histidyl hydroxylation of Rpl27a and Rpl8, respectively. This work reveals new therapeutic possibilities via oxygenase inhibition and by targeting modified over unmodified ribosomes.