Research Department
Research Journal
Org. Lett., DOI: 10.1021/ol4027733
Research Rank
1
Research Vol
Vol. 15, No. 22
Research Year
2013
Research Member
Research Abstract
A high-throughput screening of a microbial natural product library led to the discovery of two novel compounds named nivetetracyclates A and B (1 and 2), which were produced by Streptomyces niveus designated as LS2151. The backbone of the compounds contains a hydrotetracyclate not previously reported from a natural source. The structures of the compounds were elucidated by spectroscopic methods. The nivetetracyclates exhibited activity against human HeLa cells.