Synthesis, molecular modeling and anti-inflammatory screening of new 1,2,3-benzotriazinone derivatives

Faculty of Pharmacy

Assiut University

Synthesis, molecular modeling and anti-inflammatory screening of new 1,2,3-benzotriazinone derivatives

Research Authors
Tarek S. Ibrahim , Adel A. Rashad, Zakaria K. Abdel-Samii, Said A. El-Feky, Mohammed K. Abdel-Hamid, Waleed Barakat
Research Department
Department of Medicinal Chemistry
Research Journal
Medicinal Chemistry Research
Research Publisher
Springer International Publishing AG
Research Rank
1
Research Vol
Vol 21, No. 12
Research Website
NULL
Research Year
2012
Research Member
Mohammed Kamal Abdel-Hamid Amin
Research Abstract

Several new 4(3H)-1,2,3-benzotriazinone derivatives were synthesized and tested for their anti-inflammatory activity and ulcerogenic effect. A docking study on the COX-2 binding pocket has been carried out for the target compounds to rationalize the possible selectivity. Among the tested compounds, the benzotriazinones linked to either thiadiazole (8) or oxadiazole (9) evoked the highest anti-inflammatory activity as well as the best binding profiles into the COX-2 binding site.