A new cytotoxic sesquiterpene and three anti-inflammatory flavonoids of the Egyptian Tanacetum santolinoides.

Faculty of Pharmacy

Assiut University

A new cytotoxic sesquiterpene and three anti-inflammatory flavonoids of the Egyptian Tanacetum santolinoides.

Research Authors
Sabrin RM Ibrahim, Badr JM, El Sayed KA, Youssef DTA
Research Department
Department of Pharmacognosy
Research Journal
Natural Product Communications
Research Publisher
NULL
Research Rank
1
Research Vol
2
Research Website
NULL
Research Year
2007
Research Member
Sabrin Ragab Mohamed Ibrahim
Research Abstract

A re-investigation of the methanolic extract of the aerial parts of Tanacetum santolinoides has resulted in the isolation of a new sesquiterpene, tanacetonic acid (1), along with three known methoxylated flavonoids. The structure of the isolated compounds
was secured based on their IR, UV, 1D and 2D (1H-1H COSY, HSQC and HMBC) NMR spectroscopic and FAB mass spectral characteristics. The new sesquiterpene showed a significant cytotoxic activity when tested using the brine shrimp bioassay,while the three flavonoids demonstrated anti-inflammatory effects in the rat paw oedema test.