Domperidone is a dopamine antagonist antiemetic drug, water-insoluble and weakly basic with poor dissolution rates at high pH values. The current study aimed to improve such dissolution via adsorbates and co-adsorbates formulations. Adsorbates of drug with Avicel PH 101, Florite R and Aerosil 200 were prepared in different weight ratios by physical mixing, grinding and solvent deposition methods. Co-adsorbates of drug with Tween 80 and Aerosil 200 were prepared by solvent deposition method in different weight ratios. These systems were characterized using Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), powder X-ray diffractometry (P-XRD) and in-vitro dissolution. The results showed marked enhancement of domperidone dissolution at both pH1.2 and pH6.8 (7 fold and 5 fold, respectively) compared to drug alone.
Research Department
Research Journal
1st international conference on "Health between nutrition and treatment", faculty of pharmacy, Beni-suef university, Egypt
Research Publisher
NULL
Research Rank
4
Research Vol
NULL
Research Website
NULL
Research Year
2015
Research Member
Research Abstract