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Stigmasterol Tetracosanoate, a New Stigmasterol Ester from the Egyptian Blepharis ciliaris

Research Authors
M. A. El-Shanawany, H. M. Sayed, S. R. M. Ibrahim and M. A. A. Fayed
Research Department
Research Journal
Drug Research, DOI: 10.1055/s-0034-1382064
Research Publisher
Thieme
Research Rank
1
Research Vol
Vol. 65, No. 7
Research Website
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1382064
Research Year
2015
Research Member
Research Abstract

A new stigmasterol ester: stigmasterol tetracosanoate (3), along with 7 compounds: β-sitosterol (1), stigmasterol (2), (2S,3S,4R)-2[(2′R)-2′-(hydroxyeicosanoyl amino) octadecane-1,3,4-triol (4), apigenin (5), β-sitosterol-3-O-β-D-glucopyranoside (6), stigmasterol-3-O-β-D-glucopyranose (7), and apigenin-7-O-β-D-glucopyranoside (8) were isolated from Blepharis ciliaris aerial parts. Compounds 1, 2, and 5–7 are reported here for the first time from the plant and 4 for the first time from the family. GCMS analysis revealed the presence of 45 fatty acids, 53 hydrocarbons, and 24 sterols. The different fractions exhibited mild cytotoxic in brine shrimp assay and anti-hyperglycaemic activities. The EtOAc fraction and TME (total MeOH extract) showed weak anti-malarial activity against P. falciparum. The CHCl3 fraction gave potent ¬anti-inflammatory activity compared with indomethacin.