Lipoxygenase Inhibitors from Latex of Calotropis Procera (Ait) R. Br.

Faculty of Pharmacy

Assiut University

Lipoxygenase Inhibitors from Latex of Calotropis Procera (Ait) R. Br.

Research Authors
Wael M. Abdel-Mageed, Nadia H. Mohamed, Miaomiao Liu, Ali A. El-Gamal, Omer A. Basudan, Huanqin Dai, Mady Ahmed Ismail, Ronald J Quinn, Xueting Liu, Lixin Zhang, Ahmed A. M. Shoreit
Research Department
Department of Pharmacognosy
Research Journal
Archives of Pharmacal Research
Research Publisher
Springer
Research Rank
1
Research Vol
NULL
Research Website
http://link.springer.com/article/10.1007/s12272-016-0725-9
Research Year
2016
Research Member
Wael Mostafa Abdel-Mageed Mostafa
Research Abstract

Abstract
A radical-scavenging, guided phytochemical study of the latex of Calotropis Procera afforded five lignans (1–5), including a new one (4). The structural determination was accomplished using 1D- and 2D-NMR, high-resolution electrospray ionization mass spectrometry (HRESIMS), and correlation with known compounds. Among the isolated compounds, acylated lignans (3–5) showed stronger antioxidant activity than non-acylated derivatives (1,2). Anti-inflammatory activity was evaluated by determining the inhibitory potential against 5- and 15-lipoxygenase enzymes. The highest anti-inflammatory activity was observed in compound 4, with IC50s values of 7.6 µM and 2.7 µM against 5-LOX and 15-LOX, respectively.