Pencil graphite electrode was success-fully modified with a thin film of poly (eriochrome black T) and applied for the sensitive and selective voltammetric simultaneous determination of pantoprazole sodium and domperidone in a binary mixture. The preparation and basic electrochemical behavior of poly (eriochrome black T) film on the Pencil graphite electrode were investigated. The modified electrode has exhibited very high electro-catalytic activity towards the cited mixture. The anodic peaks of the both species were well defined with enhanced oxidation peak currents. Under the optimum conditions, the linearity ranges were 0.4–55 ×10−7 M and 0.1–34 × 10−7 M for pantoprazole sodium and domperidone, respectively with detection limits of 0.12 × 10−7 M and 0.04 × 10−7 M for pantoprazole sodium and domperidone, respectively. The proposed sensor has been successfully applied in the analysis of pantoprazole sodium and domperidone in synthetic binary mixtures and human serum.
Research Department
Research Journal
Materials Science and Engineering C: Materials for Biological Application
Research Publisher
ELSEVIER
Research Rank
1
Research Vol
Vol. 75
Research Website
http://dx.doi.org/10.1016/j.msec.2017.02.092
Research Year
2017
Research Member
Research Abstract