The effect of adding surfactants to electrolyte containing rabeprazole sodium (RAB sodium) on its voltammetric response at pencil graphite electrode (PGE) was explored. The current signal due to the oxidation process as a function of the amount of the cited drug, pH of the medium, type of surfactant and accumulation time at the electrode surface was evaluated. The use of sodium dodecyl sulphate in the presence of Britton-Robinson buffer (pH=6.0) for the electrochemical determination of RAB sodium using cyclic voltammetry (CV) and Square wave adsorptive stripping voltammetry (SWAdSV) at PGE was studied. The oxidation peak current has varied linearly with the drug concentration over the range of 0.006-2.5×10-7 M and 0.5-250 μM using SWAdSV and CV, respectively. The limit of detection was found to be 0.2 nM and 0.18 μM using SWAdSV and CV, respectively. The validity of the proposed method for the determination of the studied drug in pure, pharmaceutical formulation in addition to urine was conducted.