In this study, the oxidation of rabeprazole sodium (RAB Na+), a widely used anti-ulcer drug, was investigated at
a modified poly (bromocresol green)/ pencil graphite electrode (poly (BCRG)/PGE). A disposable, sensitive and
selective electrochemical platform is proposed for the determination of RAB Na+ by recording its cyclic voltammetry
(CV) and square wave adsorptive voltammetry (SWV) in Britton-Robinson buffer solution at pH of 7.0 using the
modified PGE. The poly BCRG/PGE displayed a good electrochemical behaviour with significant enhancement of the
peak current compared to the bare PGE. Under experimental conditions, the modified electrode had a linear response
range from 10-180 × 10-8 M and 3-330 × 10-7 M for SWV and CV, respectively. The detection limit was found to be 3
× 10-8 M and 1 × 10-7 M for SWV and CV, respectively. These voltammetric methods were successfully applied for the
direct determination of RAB Na+ in real samples. The effect of various interfering substances on the RAB Na+ peak
current was also investigated