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Temperature and pH dual-stimuli responsive polymeric carriers for drug delivery

Research Authors
Sara A. Abouelmagd, Noura Hassan Abd Ellah and Basma Nagi Abdel Hamid
Research Department
Research Journal
Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications(1st Edition)
Research Publisher
Elsevier (Imprint: Woodhead Publishing)
Research Rank
1
Research Vol
Volume 2: Advanced Nanocarriers for Therapeutics
Research Website
https://www.elsevier.com/books/stimuli-responsive-polymeric-nanocarriers-for-drug-delivery-applications/makhlouf/978-0-08-101995-5
Research Year
2018
Research Abstract

Environment-responsive drug delivery systems have emerged as attractive alternative to traditional systems, delivering therapeutic agents on-demand to their target tissue. Temperature and pH arise as two of the most commonly utilized stimuli for triggering these responses. Among polymeric carriers, temperature and pH dual-responsive nanocarriers were developed to exhibit changes in drug release rate or particle size upon change in environment’s pH and temperature. In this chapter, various design aspects of temperature- and pH -dual-responsive polymeric nanocarriers are discussed in details with examples, illustrating different responsive polymeric materials used in their fabrication. The interplay between temperature- and pH-responsiveness within the polymeric nanocarriers are discussed too.