Environment-responsive drug delivery systems have emerged as attractive alternative to traditional systems, delivering therapeutic agents on-demand to their target tissue. Temperature and pH arise as two of the most commonly utilized stimuli for triggering these responses. Among polymeric carriers, temperature and pH dual-responsive nanocarriers were developed to exhibit changes in drug release rate or particle size upon change in environment’s pH and temperature. In this chapter, various design aspects of temperature- and pH -dual-responsive polymeric nanocarriers are discussed in details with examples, illustrating different responsive polymeric materials used in their fabrication. The interplay between temperature- and pH-responsiveness within the polymeric nanocarriers are discussed too.