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The Use of Separation Techniques in the Analysis of Some Antiepileptic Drugs: A Critical Review

Research Authors
F.A. Mohamed, M.F. Bakr, A.H. Rageh, A.M. Mostafa
Research Journal
Journal of Liquid Chromatography & Related Technologies
Research Publisher
Taylor and Francis
Research Rank
1
Research Vol
Vol. 39
Research Website
https://www.tandfonline.com/doi/abs/10.1080/10826076.2016.1266654
Research Year
2016
Research Member
Research Abstract

In the last few decades, many new antiepileptic drugs came out to medicine world, and their use was expanded over a wide range of cases. Analysts from all over the world developed many different separation methods for the determination of these drugs in a quantitative way either in pharmaceutical dosage forms or in biological fluids. In this review article, a summation of previously published separation methods including
high-performance thin-layer chromatography, high-performance liquid chromatography, gas chromatography, and electrophoresis used for the determination of eslicarbazepine acetate, levetiracetam, lacosamide, oxcarbazepine, pregabalin, and retigabine are presented. These six drugs are the most commonly used drugs for the treatment of patients diagnosed with partial onset seizures. This article can help researchers and
analysts to build upon this knowledge and add further methods of analysis in the future.