The ethyl acetate fraction of the dried aerial parts of Senecio glaucus
L. exhibited significant antimicrobial activity against some of
selected bacteria and fungi. Also, it showed potent cytotoxicity
against PANC-1 cancer cell lines under glucose deficient medium.
The ethyl acetate fraction was subjected to different chromatographic
techniques for isolation of the bioactive compounds. A
new benzofuran glucoside; 2,3-dihydro-3b-hydroxyeuparin 3-Oglucopyranoside
(1) was isolated. Additionally, two known flavonoid
compounds isorhamentin 3-O-b-D-glucoside (2), and isorhamentin
3-O-b-D-rutinoside (3) were first identified in S. glaucus.
Compound 1 exhibited potent antimicrobial activities against two
Gram-positive bacteria, one Gram-negative bacteria, and two
fungi. Also, it displayed potent cytotoxic activity against PANC-1
cancer cell lines under glucose deficient medium (IC50 7.5 lM).
However, the isolated flavonoid glycosides (2 & 3) showed moderate
antimicrobial activities against two Gram-positive bacteria,
two Gram-negative bacteria, four fungi, and did not show any
cytotoxic activity against PANC-1.