Certain new derivatives of 1,2,4-triazolo[1,5-a]pyrimidines were synthesized through the reaction
of 1,2,4-triazolo[1,5-a]pyrimidine-7-ol with ethyl bromoacetate to afford the ethyl acetate
ester, which upon hydrazinolysis gives the corresponding hydrazide. The hydrazide is the key
intermediate which was used for the synthesis of the target compounds. The structures of the
new compounds were assigned by spectral and elemental methods of analyses. The synthesized
compounds were tested for their in vitro antibacterial and antifungal activities. Most of the
tested compounds showed comparable results with those of ampicillin and fluconazole reference
drugs.