Crystal structure and Hirshfeld surface analysis of 5-acetyl-3-amino-6-methyl- N -phenyl-4-[( E )-2-phenylethenyl]thieno[2,3- b ]pyridine-2-carboxamide

Faculty of Pharmacy

Assiut University

Crystal structure and Hirshfeld surface analysis of 5-acetyl-3-amino-6-methyl- N -phenyl-4-[( E )-2-phenylethenyl]thieno[2,3- b ]pyridine-2-carboxamide

Research Authors
Shaaban K. Mohamed, Etify A. Bakhite, Sevim Tu¨rktekin Celikesir, Hajjaj H. M. Abdu-Allah, Mehmet Akkurt, Omaima F. Ibrahim, Joel T. Mague, Safiyyah A. H. Al-Waleedy
Research Date
Research Department
Department of Pharmaceutical Organic Chemistry
Research Journal
Acta Crystallographica Section E CRYSTALLOGRAPHIC COMMUNICATIONS
Research Publisher
IUCr's
Research Vol
E78
Research Website
https://scripts.iucr.org/cgi-bin/paper?S2056989022000743
Research Year
2022
Research Member
Hajjaj Hassan Mohamed Abdu-Allah
Research_Pages
225-230
Research Abstract

The asymmetric unit of the title compound, C 25 H 21 N 3 O 2 S, comprises four molecules. Their conformations differ primarily in the orientations of the styryl and the N -phenylcarboxamido groups. In the crystal, intermolecular N—H...N, C—H...O and C—H...S hydrogen-bonding contacts as well a C—H...π(ring) interactions lead to the formation of a layer structure parallel to (010). Hirshfeld surface analysis revealed that H...H interactions represent the main contributions to the crystal packing.