Research Department
Research Journal
Digest Journal of Nanomaterials and Biostructures
Research Publisher
Forum of chalcogeniders
Research Vol
6
Research Year
2011
Research Member
Research_Pages
1129-1139
Research Abstract
In the present investigation three lipids namely, compritol 888ATO, compritol E and
precirol ATO5 were used for loading the hydrophilic drug dextromethorphane. The aim of
this investigation was to find the possibility of the tested lipids to carry a hydrophilic drug
and controlling its release. The spray drying technique was applied to produce the lipid
loaded dextromethorphan in a microparticles. The results reveald the formation of nearly
spherical microparticles with plausible yield and entrapment. DSC and FTIR showed the
presence of interaction between dextromethorphan and the tested lipids. The release of
drug from the prepared microparticles resulted in expulsion of dextromethorphan from the
microparticles of compritol E and precirol ATO5 in a fast rate. However, compritol
888ATO microparticles released the drug mor slowly. It was concluded that compritol
888ATO appear as a promising lipid for sustaining the release of dextromethorphan.