Five types of heterocyclic compounds containing trifloromethylpyridine
scaffold namely; 3-cyano-2-(Nphenyl)
carbamoylmethylthio-6-(thiophen-2-yl)-4-trifluoromethyl-
pyridine (6a), thieno[2,3-b]pyridines 3–5 and 7a–c,
pyrido[3’,2’:4,5]thieno[3,2-d] pyrimidines 8–13 and 15a–c,
pyrido[3’,2’:4,5]thieno[3,2-d][1,2,3]triazines 16a,b, and 9-(thiophen-
2-yl)-7-(trifluoromethyl) pyrido [3’,2’:4,5]thieno[2,3-
e][1,2,4]triazolo[1,5-c]pyrimidine (14) were synthesized in excellent
yields and very pure state. The structures of these
compounds were confirmed by elemental and spectral analyses.
Most of the synthesized compounds were evaluated as
insecticidal agents toward Aphis gossypii insects and promising
results obtained. Among all tested compounds, only 6, 7a, 7c
and 15c being the most potent compounds against nymphs
and adults of Aphis gossypii and their activities are nearly to
that of acetamiprid as a reference. The effect of 6a compounds
7a, 7c and 15c on the Aphis digestive system from histological
point of view was also included.