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Pyrazoles and Pyrazolo[4,3-e]pyrrolo[1,2-a]pyrazines, I. Synthesis and Microbial Activity

Research Authors
Abdel-Rahman Farghaly and Hussein El-Kashef
Research Abstract

The synthesis of the title compounds was achieved using 1-phenyl-5-(pyrrol-1-yl)-1H-pyrazole-3-carboxylic acid azide as starting material. The latter compound was allowed to react with alcohols and amines to afford the corresponding carbamates and urea derivatives. Alkaline hydrolysis of the carbamates gave the corresponding amine, which was acylated and/or aroylated to give amide derivatives. These and the urea derivatives were subjected to cyclodehydration to give the title compounds. Antibacterial and antifungal activities were observed for several derivatives

Research Department
Research Journal
Monatshefte für Chemie
Research Publisher
Springer Wien
Research Rank
1
Research Vol
Vol. 136, No. 2
Research Year
2005
Research Pages
pp. 371-376