perfluorooctanoic acid (PFOA)has similar characteristics to perfluorooctane sulfonate (PFOS) in reproduction toxicity featured by neonatal death.
We found that PFOS exposure to mice during pregnancy led to intracranial blood vessel dilatation of fetuses accompanied by severe lung collapse which caused neonatal mortality.
Thus we adopted the corresponding experimental design to PFOS in order to characterize the neonatal death by PFOA.
1,5 and 10 mg/kg PFOA were given to pregnant ICR mice daily by gavage from gestation day (GD) 0 to GD 17 and 18 for prenatal and postnatal evaluation respectively.
This research showed that the cause of neonatal death by PFOA may be different from PFOS.