Abstract This paper evaluates the anti-tumor effect of Roxithromycin (RXM) on
hepatocarcinogenesis. Histopathologically, proliferative and neoplastic changes were the
main lesions induced in liver of rats by Nnitrosodiethylamine (NDEA) and carbon
tetrachloride (CCL 4). Computerized morphometrical analysis revealed that treatment with
RXM reduced the number and size of the eosinophilic preneoplastic foci as well as inhibited
the development of large cell dysplasia, hepatoma and hepatocellular carcinoma in nearly