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Protective effect of Nigella sativa on 4-nonylphenol-induced nephrotoxicity in Clarias gariepinus (Burchell, 1822)

مؤلف البحث
Ahmed M. Kotb, Mahmoud Abd-Elkareem, Nasser S. Abou Khalil, Alaa El-Din H. Sayed
ملخص البحث

The aimof this studywas to examine the protective effects of Nigella sativa (N. sativa) on 4-Nonylphenol-induced
nephrotoxicity in Clarias gariepinus. 30 fishes were divided into five groups: control, 4-nonylphenol-treated, 1%
N. sativa treated, 2.5% N. sativa treated, and 5% N. sativa treated. N. sativa and 4-Nonylphenol were given for
3weeks. 4-NP and 4-NP-N. sativa treated fishes were comparedwith the control group. Kidney histology, immunochemistry,
and electron microscope were assessed after 4-NP exposure. In the African catfish, 4-NP is mainly
excreted through the kidney causing nephrotoxicity. Our results showed that 4-NP administration significantly
disturbed the kidney structure and function. 4-NP treated fishes showed dilated glomerular vessels, fewer glomerular
cells content, decreased expressions of glomerular proteins, and increased level of autophagy compared
to control group (P b 0.05). As N. sativa has different immunological and pharmacological effects such as anti-apoptotic
and anti-oxidant, therefore, the administration of N. sativawith 4-Nonylphenol significantly minimize the
nephrotoxic effect of 4-NP and maintain the normal kidney structure and function. Our novel study demonstrated
for the first time that N. sativa could protect the kidney against 4-NP induced-nephrotoxicity.

مجلة البحث
Science of the Total Environment
المشارك في البحث
الناشر
elsevier
تصنيف البحث
1
عدد البحث
17;619-620
موقع البحث
www.elsevier.com/locate/scitotenv
سنة البحث
2017
صفحات البحث
692–699