The goal of this study was to evaluate the effect of
unilateral ureteral ligation on blood constituents, renal
histopathology and ultrasonography in dogs. A total number
of 25 apparently healthy adult mongrel dogs found Assiut
City, Egypt, were subjected to study. Animals were divided
into five equal groups: the left ureter was ligated for 2, 7, 14
and 21 days in groups, I, II, III and IV, respectively, while
group Vrepresented the control group. The animals in groups
I, II, III and IV were euthanized on days 2, 7, 14 and 21,
respectively. Right and left uretronephrectomies were
performed and specimens were taken for the histopathological
examination. Results revealed significant increases in total
leucocytes and neutrophils counts from day 2 to day 17. There
were significant decreases (p<0.01) in total red blood cell
(RBC) count and packed cell volume (PCV)% at day 14.
Creatinine level was significantly increased on days 7
and 17. Histopathological changes were varied from
glomerular swelling and congestion to glomerular atrophy.
In conclusion, serum creatinine was highest on days 3 and 7,
while creatinine clearance was lowest at day 7. The serum blood urea nitrogen (BUN) was the highest at day 21. Major
histopathological changes were observed on day 21. These
changes were compatible with the ultrasonographic and
biochemical findings.